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[Merkel cell tumor].

A De Cesare1, M Bononi, G Bianchi

  • 1I Cattedra di Patologia Speciale Chirurgica, Università degli studi di Roma La Sapienza.

Annali Italiani Di Chirurgia
|September 1, 1990
PubMed
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Merkel cell carcinoma, a rare skin cancer, requires further study for definitive diagnosis and improved treatments. Surgical removal with lymph node dissection is currently the preferred approach for this aggressive neoplasm.

Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Merkel cell carcinoma (MCC) is a rare and aggressive skin neuroendocrine tumor.
  • It originates in the dermis, without epidermal involvement, and presents unique histopathological features.

Observation:

  • Review of 274 literature cases and one observed case of Merkel cell carcinoma.
  • Detailed description of MCC's anatomopathological characteristics.
  • Emphasis on immunohistochemistry for differential diagnosis against lymphoma, amelanotic melanoma, and metastatic carcinoma.

Findings:

  • Surgical excision combined with prophylactic regional lymphadenectomy is the primary treatment modality.
  • The role of radiotherapy and chemotherapy is not standardized but shows encouraging results, particularly for relapses or metastatic disease.

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  • Current data are limited, necessitating further research into MCC's histogenesis and pathology.

    • Implications:

    • Further research is crucial for precise definition and improved therapeutic strategies for Merkel cell carcinoma.
    • Enhanced understanding may lead to reduced mortality rates associated with this aggressive skin cancer.
    • Multidisciplinary approaches integrating surgery, radiotherapy, and chemotherapy may be beneficial in managing advanced or recurrent cases.