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Uranyl ion-catalyzed synthesis of several 8-substituted 2'-5'-oligoadenylates, and their properties
1Department of Chemistry, Faculty of Engineering, Gunma University, Japan.
Nucleic Acids Symposium Series
|January 1, 1990
Abstract:
We have synthesized 2'-5' linked oligomers from 8-substituted adenosine-5'-phosphorimidazolides using uranyl ion catalyst. 8-amino derivative, as highly susceptible to hydrolysis, gave short chained oligomers in a low yield, while the rest of 8-substituted or unsubstituted derivatives gave the corresponding oligomers in high yields. Properties of 8-substituted 2'-5' oligomers were studied applying spectrometer and through enzymatic digestion.