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[Evaluation of insulin sensitivity in diabetes using the euglycemic hyperinsulinemic clamp method]
D Micić1, V Popović, M Sumarac
1Institute of Endocrinology, Diabetes and Diseases of Metabolism University Clinical Centre, Belgrade.
Srpski Arhiv Za Celokupno Lekarstvo
|September 1, 1990
Summary
Non-insulin dependent diabetes mellitus shows significantly lower peripheral insulin sensitivity compared to insulin dependent diabetes mellitus and healthy individuals. The artificial endocrine pancreas effectively assesses insulin sensitivity for therapeutic evaluation.
Area of Science:
- Endocrinology
- Metabolic Research
Context:
- Peripheral insulin sensitivity is crucial for glucose homeostasis.
- Diabetes mellitus is characterized by impaired insulin action.
- Artificial endocrine pancreas offers a method for assessing insulin sensitivity.
Purpose:
- To assess peripheral insulin sensitivity in patients with insulin dependent diabetes mellitus (IDDM) and non-insulin dependent diabetes mellitus (NIDDM) using an artificial endocrine pancreas.
- To compare insulin sensitivity between diabetic subtypes and healthy controls.
Summary:
- Peripheral insulin sensitivity was evaluated in 15 diabetics (6 IDDM, 9 NIDDM) and 10 controls using an artificial endocrine pancreas.
- NIDDM patients exhibited significantly lower insulin sensitivity (RC = 2.30 +/- 1.37) compared to IDDM (RC = 5.88 +/- 2.89) and controls (RC = 4.93 +/- 1.96).
- No significant difference in insulin sensitivity was observed between IDDM and control groups.
Impact:
- This study highlights potential pathogenetic mechanisms of insulin resistance in NIDDM.
- The artificial endocrine pancreas and euglycemic clamp technique are valuable tools for assessing therapeutic interventions on insulin sensitivity.