Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autophagy01:27

Autophagy

Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
Delivery Pathways to the Lysosome01:36

Delivery Pathways to the Lysosome

Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
Cellular Injury V: Apoptosis and Autophagy01:22

Cellular Injury V: Apoptosis and Autophagy

Cells respond to damage and stress through highly coordinated processes that decide whether they survive or undergo controlled self-destruction. Two major pathways involved in this regulation are apoptosis, a type of programmed cell death, and autophagy, a survival mechanism that helps cells adapt to adverse conditions.ApoptosisApoptosis removes aged or injured cells to maintain tissue balance. During this process, the cell shrinks, chromatin condenses and fragments, and membrane-bound...
Autophagic Cell Death01:18

Autophagic Cell Death

Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and pro-apoptotic...
Introduction to Metabolism01:30

Introduction to Metabolism

Metabolism encompasses all biochemical reactions in a living organism, facilitating both the breakdown and synthesis of biomolecules. These metabolic processes are categorized into catabolic and anabolic pathways, which operate in a coordinated manner to ensure energy balance and cellular function.Catabolic Pathways and Energy ReleaseCatabolic pathways involve the breakdown of complex macromolecules such as carbohydrates, lipids, and proteins into smaller structures like monosaccharides, fatty...
Other Glycolytic Pathways01:24

Other Glycolytic Pathways

The pentose phosphate pathway (PPP) operates in parallel with glycolysis, facilitating the metabolism of both pentoses and glucose. This pathway consists of two distinct phases: the oxidative and non-oxidative phases. While it does not directly generate ATP, the intermediates formed during the process can integrate into glycolysis, contributing to cellular energy metabolism when required.Oxidative Phase: NADPH ProductionThe oxidative phase of the pentose phosphate pathway is primarily...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unraveling the intersection of aging and Parkinson's disease: a collaborative roadmap for advancing research models.

NPJ Parkinson's disease·2026
Same author

Effectiveness of ustekinumab in patients with psoriatic arthritis in a real-world, multicenter study.

Clinical rheumatology·2020
Same author

Monitoring spatiotemporal changes in chaperone-mediated autophagy in vivo.

Nature communications·2020
Same author

Analysis of Chaperone-Mediated Autophagy.

Methods in molecular biology (Clifton, N.J.)·2019
Same author

Autophagy and regulation of cilia function and assembly.

Cell death and differentiation·2014
Same author

Chaperone-mediated autophagy.

Methods in molecular biology (Clifton, N.J.)·2008

Related Experiment Video

Updated: Jun 7, 2026

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy
07:20

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy

Published on: January 31, 2025

Autophagic pathways and metabolic stress.

S Kaushik1, R Singh, A M Cuervo

  • 1Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Diabetes, Obesity & Metabolism
|October 30, 2010
PubMed
Summary
This summary is machine-generated.

Autophagy, a cellular process, defends against metabolic stress from faulty proteins and lipids. Dysfunctional autophagy may contribute to common metabolic disorders.

More Related Videos

Activating Autophagy by Aerobic Exercise in Mice
08:44

Activating Autophagy by Aerobic Exercise in Mice

Published on: February 3, 2017

Visualizing Mitophagy with Fluorescent Dyes for Mitochondria and Lysosome
07:56

Visualizing Mitophagy with Fluorescent Dyes for Mitochondria and Lysosome

Published on: November 30, 2022

Related Experiment Videos

Last Updated: Jun 7, 2026

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy
07:20

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy

Published on: January 31, 2025

Activating Autophagy by Aerobic Exercise in Mice
08:44

Activating Autophagy by Aerobic Exercise in Mice

Published on: February 3, 2017

Visualizing Mitophagy with Fluorescent Dyes for Mitochondria and Lysosome
07:56

Visualizing Mitophagy with Fluorescent Dyes for Mitochondria and Lysosome

Published on: November 30, 2022

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Metabolic Biochemistry

Background:

  • Autophagy is a fundamental intracellular degradation pathway involving lysosomes.
  • Initially known for nutrient scavenging, its role in cellular stress response is increasingly recognized.
  • Metabolic stress, arising from protein or lipid imbalances, significantly impacts cellular homeostasis.

Purpose of the Study:

  • To review novel findings linking autophagic function with metabolic stress.
  • To explore the interplay between autophagy and proteotoxicity in the cytosol and endoplasmic reticulum.
  • To examine autophagy's role in lipid metabolism and its response to lipogenic challenges.

Main Methods:

  • Literature review of recent research on autophagy and metabolic stress.
  • Analysis of studies investigating proteotoxicity and autophagic defense mechanisms.
  • Examination of research on lipid metabolism and autophagy's contribution.

Main Results:

  • Autophagy is crucial for clearing misfolded proteins, preventing proteotoxicity in the cytosol and ER.
  • Autophagy plays a role in mobilizing intracellular lipid stores and regulating lipid metabolism.
  • Chronic exposure to metabolic stressors can impair autophagic function.

Conclusions:

  • Autophagy is a key player in cellular defense against diverse metabolic stressors.
  • Disruptions in autophagic activity under metabolic stress may underlie common metabolic disorders.
  • Further research into the autophagy-metabolic stress axis is warranted for therapeutic insights.