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Neurosarcoidosis affecting the vagus nerve
1Dept of Otolaryngology-Head and Neck Surgery, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA.
The Annals of Otology, Rhinology, and Laryngology
|November 2, 2010
Summary
Neurosarcoidosis affecting the vagus nerve is rare, impacting vocal fold function. This study reviewed cases, highlighting symptoms and diagnostic considerations for this cranial nerve X involvement.
Area of Science:
- Neurology
- Immunology
- Otolaryngology
Background:
- Neurosarcoidosis is a rare granulomatous disease affecting the nervous system.
- Vagus nerve (cranial nerve X) involvement is an uncommon manifestation of neurosarcoidosis.
Purpose of the Study:
- To review patients diagnosed with neurosarcoidosis affecting the vagus nerve.
- To detail the clinical presentation, disease progression, treatment strategies, and outcomes in affected individuals.
Main Methods:
- A retrospective chart review was conducted.
- Patients presenting to the medical center over a 10-year period with neurosarcoidosis specifically involving cranial nerve X were identified.
Main Results:
- Only 4 out of 53 reviewed patients had findings suggestive of vagal neurosarcoidosis.
- All affected patients were male, with a mean age of 50 years.
- Common symptoms included cough, syncope, and facial pain, with all patients exhibiting vocal fold paresis or paralysis. Magnetic resonance imaging (MRI) of the head was positive in most cases.
Conclusions:
- Neurosarcoidosis of the vagus nerve is a rare condition.
- It should be considered in the differential diagnosis of vocal fold paresis or paralysis, especially when other neurological signs are present.
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