Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Insufficient Sleep and Sleep Deprivation

Insufficient Sleep and Sleep Deprivation

Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Immune Cell Mitochondrial Respiration and Inflammatory Profiles Are Partially Modulated by Cardiorespiratory Fitness in Male Adults.

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme·2026

Same author

Exercise-induced esterified cholesterol transfer to HDL is enhanced in master endurance-trained athletes after moderate-intensity cycling.

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme·2026

Same author

Neuromuscular Electrical Stimulation Plus Nutritional Counseling Attenuates Thigh Muscle Thickness Loss in Hospitalized Cancer Patients.

Pathophysiology : the official journal of the International Society for Pathophysiology·2025

Same author

Metabolic changes explain how training mitigates the reduction in strength caused by sleep restriction.

Physiology & behavior·2025

Same author

Intrauterine growth restriction (IUGR) modifies the hypothalamic response to a systemic glucose load in adult male rats, as assessed by proteomic analysis.

Metabolic brain disease·2025

Same author

Molecular mechanism of aerobic exercise in miRNAs and the anti-tumoral effects.

Frontiers in oncology·2025

Search research articles

Related Experiment Video

Updated: Jun 7, 2026

Establishing a Device for Sleep Deprivation in Mice

Establishing a Device for Sleep Deprivation in Mice

Published on: September 22, 2023

Sleep deprivation affects inflammatory marker expression in adipose tissue.

José C Rosa Neto¹, Fábio S Lira, Daniel P Venancio

¹Departmento de Fisiologia da Nutrição, Universidade Federal de São Paulo (UNIFESP)-São Paulo/SP, Brazil. josecesar23@hotmail.com

Lipids in Health and Disease

|November 2, 2010

Summary

Ninety-six hours of paradoxical sleep deprivation in rats reduced fat mass and altered inflammatory markers in adipose tissue depots. Corticosterone increased, while leptin and triglycerides decreased in serum.

More Related Videos

Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots

Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots

Published on: August 16, 2020

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings

Published on: June 13, 2025

Related Experiment Videos

Last Updated: Jun 7, 2026

Establishing a Device for Sleep Deprivation in Mice

Establishing a Device for Sleep Deprivation in Mice

Published on: September 22, 2023

Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots

Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots

Published on: August 16, 2020

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings

Published on: June 13, 2025

Area of Science:

Endocrinology
Metabolism
Inflammation Research

Background:

Sleep deprivation is linked to increased inflammatory markers.
Inflammation is associated with obesity, cancer, and cardiovascular diseases.
Adipose tissue plays a role in regulating inflammation and metabolism.

Purpose of the Study:

To investigate the effects of paradoxical sleep deprivation on pro-inflammatory and anti-inflammatory cytokines and adipokines in rat adipose tissue.
To assess changes in lipid profiles and serum levels of corticosterone, leptin, and adiponectin following sleep deprivation.

Main Methods:

Two groups of rats: control (C) and paradoxical sleep deprivation (PSD) for 96 hours.
Analysis of interleukin (IL)-6, IL-10, and tumor necrosis factor (TNF)-α in mesenteric (MEAT) and retroperitoneal (RPAT) adipose tissue.
Measurement of serum leptin, adiponectin, glucose, corticosterone, and lipid profiles.

Main Results:

Elevated IL-6 in RPAT, unchanged IL-6 in MEAT; decreased TNF-α in MEAT; unchanged IL-10 in both depots.
Serum glucose, triglycerides, VLDL, and leptin decreased after PSD.
Serum corticosterone increased, while adiponectin remained unchanged.

Conclusions:

Paradoxical sleep deprivation reduced fat mass and modulated cytokine content in adipose tissue depots.
The inflammatory response in adipose tissue was diminished, with depot-specific changes in IL-6 and TNF-α.
Increased serum corticosterone suggests a stress response to sleep deprivation.