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A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

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Published on: August 12, 2020

Epigenetics in neonatal diseases.

Xue-feng Xu¹, Li-zhong Du

¹Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

Chinese Medical Journal

|November 2, 2010

Summary

This summary is machine-generated.

Epigenetic changes during fetal development influence neonatal diseases and adult health risks. Understanding these epigenetic modifications offers new pathways for preventing adult diseases like diabetes and hypertension.

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Area of Science:

Developmental Biology
Epigenetics
Neonatal Medicine

Background:

The "fetal origins of adult disease" hypothesis links early-life conditions to later health outcomes.
Epidemiological studies show lower birth weight correlates with increased adult disease risk (e.g., type 2 diabetes, hypertension, cardiovascular disease).
Fetal insults impacting epigenetic modifications are strongly associated with this phenomenon.

Purpose of the Study:

To review the role of epigenetic regulation in neonatal diseases.
To elucidate the connection between neonatal epigenetic changes and the "fetal origins of adult disease" hypothesis.

Main Methods:

Literature review of articles published between January 1953 and December 2009.
Focused selection of articles on epigenetics and neonatal diseases from Medline/PubMed.

Main Results:

Epigenetic modifications play a potential role in various neonatal conditions, including congenital disorders, transient neonatal diabetes mellitus (TNDM), intrauterine growth retardation (IUGR), and persistent pulmonary hypertension of the newborn (PPHN).
Fetal exposure to insults can lead to epigenetic alterations, contributing to the increased risk of adult diseases observed in individuals with lower birth weight.

Conclusions:

Recognizing the role of epigenetic modifications in neonatal diseases is crucial for understanding disease pathogenesis.
This understanding can provide novel insights for the prevention and treatment of both neonatal conditions and subsequent adult diseases.