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Updated: Jun 7, 2026
06:51
Systemic Delivery of MicroRNA Using Recombinant Adeno-associated Virus Serotype 9 to Treat Neuromuscular Diseases in Rodents
Published on: August 10, 2018
Megarole for microRNA in muscle disease
Colin G Crist1, Margaret Buckingham
1CNRS URA, Department of Developmental Biology, Institut Pasteur, Paris, France.
Cell Metabolism
|November 2, 2010
Abstract:
Deregulation of microRNAs in dystrophic muscle highlights their importance in muscle homeostasis. A recent study in Cell Metabolism (Cacchiarelli et al., 2010) shows that the presence of functional dystrophin is required for NO-dependent nitrosylation of the HDAC2 repressor and subsequent activation of a group of microRNAs required for muscle function.
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