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Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies

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¹Institut Clínic d'Oftalmologia (ICOF), Hospital Clínic I Provincial, Barcelona, Spain.

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Summary

This summary is machine-generated.

A woman experienced vision loss due to non-arteritic ischemic optic neuropathy. This occurred despite a negative temporal artery biopsy, highlighting potential sildenafil risks in women with specific health conditions.

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Published on: March 5, 2020

Area of Science:

Ophthalmology
Nephrology
Cardiology

Background:

A 63-year-old woman with end-stage renal disease on hemodialysis, arterial hypertension, and pulmonary hypertension was treated with sildenafil.
The patient presented with consecutive visual loss.

Observation:

Temporal artery biopsy was performed and was negative for giant cell arteritis.
Bilateral, consecutive non-arteritic ischemic optic neuropathy was diagnosed.

Findings:

The patient's visual loss was attributed to non-arteritic ischemic optic neuropathy.
Sildenafil use was considered a potential contributing factor.

Implications:

This case highlights the potential risks of sildenafil in women, particularly those with pre-existing cardiovascular and renal conditions.
Further research is warranted to understand the safety profile of sildenafil in female populations.