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Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Gene-Environment Interactions01:20

Gene-Environment Interactions

Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...

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Related Experiment Video

Updated: Jun 7, 2026

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
14:56

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Published on: May 6, 2022

Epigenetics and obesity.

Javier Campión1, Fermin Milagro, J Alfredo Martínez

  • 1Department of Food Sciences, Physiology and Toxicology, University of Navarra, Pamplona, Spain.

Progress in Molecular Biology and Translational Science
|November 2, 2010
PubMed
Summary

Epigenetics, the study of gene expression changes without altering DNA, is a key factor in obesity. Identifying epigenetic markers can predict weight changes and guide personalized weight management strategies.

Area of Science:

  • Obesity research
  • Epigenetics
  • Metabolic health

Background:

  • Obesity stems from multifactorial causes including genetics, neuroendocrine factors, fetal programming, and environmental influences like poor diet and inactivity.
  • Epigenetics, heritable gene expression changes without DNA sequence alteration, is increasingly recognized as a crucial determinant in obesity development.

Purpose of the Study:

  • To highlight the role of epigenetics in obesity etiology.
  • To explore how epigenetic mechanisms, influenced by diet, contribute to weight gain.
  • To investigate the potential of epigenetic markers for predicting weight susceptibility and informing personalized interventions.

Main Methods:

  • Review of experimental evidence linking dietary factors to epigenetic modifications.

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Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography
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Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography

Published on: April 4, 2012

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Last Updated: Jun 7, 2026

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
14:56

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Published on: May 6, 2022

Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography
13:09

Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography

Published on: April 4, 2012

  • Analysis of epigenetic mechanisms such as DNA methylation and histone modifications.
  • Exploration of weight homeostasis regulation through epigenetic pathways.

    • Main Results:

    • Dietary factors can influence obesity development via epigenetic mechanisms.
    • Epigenetic alterations like DNA methylation and histone modifications are implicated in weight regulation.
    • Identifying individuals with specific epigenetic profiles may predict weight gain or loss susceptibility.

    Conclusions:

    • Epigenetic mechanisms are significant determinants of obesity.
    • Epigenetic profiling can aid in predicting weight management outcomes.
    • Further research into epigenetics may lead to novel preventative and therapeutic strategies for obesity.