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Related Concept Videos

Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
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Viruses are unique biological entities that blur the boundary between living and non-living systems. Although they lack cellular structure and metabolic processes, they can exhibit characteristics of life when infecting a host. Their defining feature is a nucleic acid core, composed of either DNA or RNA, encapsulated within a protein coat called a capsid. This simple structure allows them to invade host cells and use their machinery for replication efficiently.Viral Structure and...
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Updated: Jun 7, 2026

Combined Genetic and Chemical Capsid Modifications of Adenovirus-Based Gene Transfer Vectors for Shielding and Targeting
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Combined Genetic and Chemical Capsid Modifications of Adenovirus-Based Gene Transfer Vectors for Shielding and Targeting

Published on: October 26, 2018

Chemically modified viruses: principles and applications.

Kristopher J Koudelka1, Marianne Manchester

  • 1Department of Molecular Biology, The Scripps Research Institute, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA.

Current Opinion in Chemical Biology
|November 2, 2010
PubMed
Summary
This summary is machine-generated.

Viruses are emerging as versatile natural nanomaterials for advanced applications. Chemical modification strategies are enabling new uses in materials development and therapeutic design.

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Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry
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Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry

Published on: August 19, 2012

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Last Updated: Jun 7, 2026

Combined Genetic and Chemical Capsid Modifications of Adenovirus-Based Gene Transfer Vectors for Shielding and Targeting
08:14

Combined Genetic and Chemical Capsid Modifications of Adenovirus-Based Gene Transfer Vectors for Shielding and Targeting

Published on: October 26, 2018

Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry
12:31

Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry

Published on: August 19, 2012

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Virology

Background:

  • Viruses, traditionally viewed as pathogens, are increasingly recognized for their potential as natural nanomaterials.
  • Advances in understanding viral structure and function facilitate their repurposing for non-pathogenic applications.

Purpose of the Study:

  • To review recent chemical strategies for modifying viruses.
  • To highlight the applications of virus-based molecular materials in various fields.

Main Methods:

  • Discussion of chemical modification techniques applicable to viral substrates.
  • Review of literature on the development and application of modified viruses.

Main Results:

  • Demonstration of diverse chemical approaches for tailoring viral properties.
  • Examples of successful applications in materials science and therapeutic design.

Conclusions:

  • Chemical modification unlocks the potential of viruses as adaptable molecular building blocks.
  • Virus-based nanomaterials offer promising avenues for future technological innovation.