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Updated: Jun 7, 2026

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
Published on: June 6, 2025
PAFc, a key player in MLL-rearranged leukemogenesis
Jiaying Tan1, Andrew G Muntean, Jay L Hess
1Department of Pathology, University of Michigan Medical School, 5240 Medical Sciences 1, 1301 Catherine Avenue, Ann Arbor MI 48109, USA.
Abstract:
Recent studies identified an interaction between the Polymerase Associated Factor complex (PAFc) and Mixed Lineage Leukemia (MLL), including MLL-rearranged oncoproteins. This interaction is critical for MLL transcriptional activity and MLL-rearranged leukemogenesis. Here, we discuss the potential molecular role of the PAFc in transcriptional dysregulation of MLL target genes and the interplay between PAFc and MLL-rearranged oncoproteins in leukemogenesis.
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