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Sing the mind electric - principles of deep brain stimulation
Morten L Kringelbach1, Alexander L Green, Sarah L F Owen
1University of Oxford, Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, UK. Morten.Kringelbach@psych.ox.ac.uk
The European Journal of Neuroscience
|November 3, 2010
Summary
Deep brain stimulation (DBS) shows promise for treatment-resistant disorders by restoring brain network oscillations. Future research could refine DBS for conditions like anhedonia, but caution is advised.
Area of Science:
- Neuroscience
- Neuromodulation
- Psychiatry
Background:
- Deep brain stimulation (DBS) is effective for treatment-resistant disorders, but its neural mechanisms remain unclear.
- Translational research is advancing the understanding of DBS.
- Restoring normal brain network activity is a key emerging principle.
Purpose of the Study:
- To review emerging principles of deep brain stimulation (DBS) mechanisms.
- To explore the role of DBS in restoring brain network function.
- To guide future therapeutic targets for affective disorders.
Main Methods:
- Review of translational research findings.
- Analysis of neuroscientific techniques.
- Examination of oscillatory activity in brain networks.
Main Results:
- DBS appears to restore normal oscillatory activity within key brain networks.
- DBS may rebalance the brain's default mode network.
- Potential for treating affective disorders like anhedonia.
Conclusions:
- DBS holds promise for understanding brain function and treating disorders.
- Further research is needed to optimize DBS therapies.
- Caution is necessary to avoid past neurosurgical errors.
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