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[Study on change of SCC Ag, CEA and CA15-3 in rat model of lung squamous cell carcinoma]
1Department of Pathology, Basic Medical College, Hubei Medical University, Wuhan, Hubei 430071, P.R.China.
Background:
To evaluate significance of squamous cell carcinoma associated antigen (SCC Ag) and carcinoembrynoic antigen (CEA) and carbohydrate antigen 15-3 (CA15-3) in early diagnosis of lung squamous cell carcinoma
Methods:
Lung squamous cell carcinoma was induced with methylcholanthrene (MCA) in iodized oil in Wistar rats. Ninty-one rats were used for this experiment, and the rats were sacrificed on the 20th, 40th, 50th, 60th, 70th and 80th days respectively. The stage of the cancer development including atypical hyperplasia, carcinoma in situ, early invasive carcinoma was diagnosed histopathologically. SCC Ag, CEA and CA15-3 in the serum of different conceration stage rats were measured by MEIA technique.
Results:
Serum levels of SCC Ag, CEA and CA15-3 of the model rats in the atypical hyperplasia and carcinoma in situ had no significant difference. The level of SCC Ag increased predominantly at the early invasive carcinoma(P<0.01), but the other two markers had no change.
Conclusions:
SCC Ag level in serum may be of considerable importance in the early diagnosis of lung squamous cell carcinoma.
