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Published on: January 7, 2019
[The expression of p16 and Rb proteins in non-small cell lung cancer]
1Department of Pathology, Tianjin Medical University, Tianjin 300070, P.R.China.
Background:
To study the expression of p16, Rb proteins and their relationship.
Methods:
The expression of p16, Rb in 74 cases of NSCLC and 10 cases of normal lung tissues were studied by SP immunohistochemical technique.
Results:
p16 protein deletion rate in NSCLC was 45.95%, which was higher than that in normal lung tissue (P<0.01). p16 protein deletion correlated remarkably with lymph node metastasis(P<0.01). Rb protein deletion rate in NSCLC was 28.38%. No significant correlation of Rb deletion rate was found between NSCLC and normal lung tissues (P>0.05). p16 expression showed negative correlation with Rb expression(P<0.05).
Conclusions:
p16 deletion may play an important role in the tumorigenesis and metastasis of NSCLC. There may be a negative feedback pathway between p16 and Rb.
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