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Evidence-based recommendations for treatment with methotrexate in rheumatic disorders
Ole Rintek Madsen1, Mikkel Faurschou, Anne Gitte Loft
1Department of Internal Medicine C/Rheumatology, Copenhagen University Hospital Gentofte, 2900 Hellerup, Denmark. rintek@dadlnet.dk
Danish Medical Bulletin
|November 3, 2010
Summary
New methotrexate recommendations for rheumatic disorders were developed using evidence and expertise. Danish rheumatologists showed high agreement with these guidelines, facilitating their use in clinical practice.
Area of Science:
- Rheumatology
- Evidence-Based Medicine
- Clinical Practice Guidelines
Background:
- Methotrexate is a key drug in treating rheumatic disorders.
- Developing standardized recommendations is crucial for optimal patient care.
- Assessing clinician agreement ensures guideline implementation.
Purpose of the Study:
- To develop Evidence, Expertise, Exchange (3E) recommendations for methotrexate use in rheumatic diseases.
- To evaluate the level of agreement among Danish rheumatologists with these recommendations.
Main Methods:
- Systematic literature review and Delphi consensus process.
- Development of national and multinational recommendations (RCs).
- Survey distributed to Danish rheumatologists to assess agreement with multinational RCs.
Main Results:
- 24 national RCs developed with 71-100% agreement.
- 73 rheumatologists surveyed on 10 multinational RCs, showing median agreement scores of 8-10.
- 70-100% of specialists reported using the RCs in daily practice.
- No direct conflicts identified between national and multinational RCs.
Conclusions:
- National and multinational recommendations for methotrexate therapy in rheumatic disorders were successfully developed.
- High agreement among Danish rheumatologists indicates strong support for the RCs.
- The developed RCs are applicable and utilized in clinical practice.
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