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Related Experiment Video

Updated: Jun 7, 2026

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach

Published on: May 7, 2019

ABO-incompatible kidney transplantation.

Karoline Schousboe¹, Kjell Titlestad, Francois Baudier

¹Department of Nephrology, Odense University Hospital, Denmark. kschousboe@dadlnet.dk

Danish Medical Bulletin

|November 3, 2010

Summary

ABO-incompatible kidney transplants, using antibody removal and suppression, show similar rejection and mortality rates to standard transplants. This approach expands living donor kidney transplantation options in Denmark.

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Mouse Kidney Transplantation: Models of Allograft Rejection

Mouse Kidney Transplantation: Models of Allograft Rejection

Published on: October 11, 2014

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Last Updated: Jun 7, 2026

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach

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Published on: May 7, 2019

Mouse Kidney Transplantation: Models of Allograft Rejection

Mouse Kidney Transplantation: Models of Allograft Rejection

Published on: October 11, 2014

Area of Science:

Nephrology
Transplantation Immunology

Background:

Kidney transplantation is the optimal treatment for end-stage renal disease (ESRD).
Donor kidney shortage in Denmark necessitates expanded donation options.
Odense University Hospital (OUH) introduced ABO-incompatible kidney transplantation.

Purpose of the Study:

To increase living donor kidney transplantation rates.
To maintain low rejection and mortality rates.
To address donor kidney scarcity.

Main Methods:

Retrospective evaluation of 11 patients undergoing ABO-incompatible kidney transplantation.
Utilized antigen-specific immunoadsorption to remove blood group antibodies.
Administered anti-CD20 antibody (rituximab) to inhibit antibody production.

Main Results:

One antibody-mediated and one T-cell-mediated rejection occurred, both treated effectively.
One patient died from myocardial infarction with a functioning graft.
Average serum creatinine level was 128 micromol/l.

Conclusions:

ABO-incompatible kidney transplantation at OUH achieved comparable rejection and mortality rates to ABO-compatible transplants.
The protocol is a viable option to increase kidney transplantation rates.
The method shows promise in overcoming donor organ limitations.