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A High Output Method to Isolate Cerebral Pericytes from Mouse
06:49

A High Output Method to Isolate Cerebral Pericytes from Mouse

Published on: January 14, 2020

Pericytes: blood-brain barrier safeguards against neurodegeneration?

Annelies Quaegebeur1, Inmaculada Segura, Peter Carmeliet

  • 1Vesalius Research Center, KU Leuven, B-3000 Leuven, Belgium.

Neuron
|November 3, 2010
PubMed

The role of pericytes in the control of blood-brain barrier (BBB) integrity has remained enigmatic. In this issue, Bell et al. and two concurrent studies highlight that pericyte loss causes BBB breakdown and hypoperfusion. Remarkably, these vascular changes precede neurodegeneration and cognitive defects in old age.

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