Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
Accessory Structures of the Eye01:17

Accessory Structures of the Eye

Optical perception, or vision, is an extraordinary sense dependent on converting light signals received via the ocular organs. These organs, known as eyes, are securely positioned within the bony cavities of the skull, called orbits. The orbits serve a dual purpose: a protective shield for the ocular globes and a stable attachment point for the soft ocular tissues. The eye's external protective mechanisms include the eyelids, which are edged with lashes that act as a barrier against foreign...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molecular, genetic, and pharmacological advances in type 2 diabetes (2015-2025).

Biomolecular concepts·2026
Same author

Diabetic retinopathy remission in patients using an automated insulin delivery system: A prospective controlled study.

Diabetes & metabolism·2025
Same author

Genome-wide association study provides novel insight into the genetic architecture of severe obesity.

PLoS genetics·2025
Same author

Intersecting Risk: Heat and Substance Use in Rural Communities.

Substance use & misuse·2025
Same author

Are there differences in the kinetic parameters of the vertical jump performed by beach volleyball players on different types of sand?

Sports biomechanics·2024
Same author

The Roles of Protocols and Protocolization in Improving Outcome From Severe Traumatic Brain Injury.

Neurosurgery·2023

Related Experiment Videos

Peripheral primitive neuroectodermal tumour of the orbit.

Ricardo Romero1, Ananda Castano, Jose Abelairas

  • 1Department of Paediatric Ophthalmology, University Hospital La Paz, Madrid, Spain. romeromartinricardo@hotmail.com

The British Journal of Ophthalmology
|November 3, 2010
PubMed
Summary

Peripheral primitive neuroectodermal tumours (pPNETs) are rare orbital soft-tissue tumors. Most patients with orbital pPNETs survived treatment, suggesting this form may be less aggressive.

Related Experiment Videos

Area of Science:

  • Oncology
  • Ophthalmology
  • Pathology

Background:

  • Peripheral primitive neuroectodermal tumours (pPNETs) are rare neuroepithelial soft-tissue neoplasms originating outside the central and sympathetic nervous systems.
  • Orbital pPNETs are exceptionally infrequent, with limited cases documented in medical literature.

Observation:

  • This study reviews demographics, clinical characteristics, diagnostic features, and therapeutic strategies for primary orbital pPNETs.
  • Immunohistochemical and ultrastructural analyses are crucial for differentiating orbital pPNETs from other small round cell tumors.

Findings:

  • While bone invasion and extraorbital spread can occur, systemic metastases are uncommon in orbital pPNETs.
  • Surgery is the primary treatment, often supplemented by chemotherapy and/or radiotherapy.
  • Most patients with orbital pPNETs survived follow-up, indicating a potentially less aggressive clinical course compared to other pPNETs.

Implications:

  • Accurate diagnosis of orbital pPNETs requires distinguishing them from other small round cell tumors.
  • Multimodal treatment including surgery and adjuvant therapies offers a favorable prognosis.
  • Orbital pPNETs may represent a distinct clinical entity with a better prognosis than systemic counterparts.