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Related Concept Videos

Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Stroke: Introduction and Types01:29

Stroke: Introduction and Types

A stroke is an acute neurological event caused by the sudden disruption of cerebral blood flow, leading to rapid loss of neuronal function. Neurons depend on continuous oxygen and glucose supply, so even brief interruptions can cause irreversible injury within minutes. Strokes are classified into ischemic and hemorrhagic types.Ischemic StrokeIschemic strokes are most common and occur due to arterial occlusion, depriving brain tissue of oxygen and nutrients. This leads to energy failure, ionic...
Transient Ischemic Attack l: Introduction01:26

Transient Ischemic Attack l: Introduction

A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...

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A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
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Published on: May 22, 2019

Association between weekend hospital presentation and stroke fatality.

Jiming Fang1, Gustavo Saposnik, Frank L Silver

  • 1Toronto General Hospital, 200 Elizabeth Street, Toronto, Ontario, Canada.

Neurology
|November 3, 2010
PubMed
Summary

Patients admitted to the hospital on weekends have a higher risk of stroke death compared to those admitted on weekdays. This weekend effect on stroke outcomes persists after accounting for patient severity and other factors.

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Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
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Published on: January 18, 2018

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Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
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Published on: January 18, 2018

Area of Science:

  • Neurology
  • Public Health
  • Epidemiology

Background:

  • Previous research indicates higher stroke case fatality for weekend admissions.
  • The underlying reasons for this weekend disparity in stroke outcomes remain unclear.

Purpose of the Study:

  • To investigate the association between weekend hospital admission and stroke case fatality.
  • To compare in-hospital stroke care and 7-day mortality rates between weekend and weekday stroke admissions.

Main Methods:

  • A cohort study utilized data from the Registry of the Canadian Stroke Network (n=20,657).
  • Patients with acute stroke or transient ischemic attack (TIA) admitted between 2003 and 2008 were analyzed.
  • In-hospital stroke care and 7-day all-cause stroke case fatality were compared between weekend and weekday admissions, adjusting for stroke severity and baseline factors.

Main Results:

  • Hospital presentation rates were lower on weekends, particularly for minor strokes and TIAs.
  • Key stroke care elements, including stroke unit admission and neuroimaging, were similar for weekend and weekday patients.
  • A higher 7-day all-cause fatality rate was observed for weekend admissions (8.1%) versus weekday admissions (7.0%), with an adjusted hazard ratio of 1.12 (95% CI 1.00 to 1.25).

Conclusions:

  • Stroke case fatality is significantly higher for patients admitted on weekends compared to weekdays.
  • This increased fatality risk associated with weekend admissions persists even after adjusting for patient case mix and stroke severity.