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Lateralization

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Brain lateralization refers to the division of mental processes and functions between the two hemispheres of the brain, a phenomenon that optimizes neural efficiency and underpins complex abilities in humans. This specialization allows each hemisphere to perform tasks where it has a comparative advantage, facilitating more refined cognitive capabilities across different domains.

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Related Experiment Video

Updated: Jun 7, 2026

Frontal Disconnection for Treating Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia in Epilepsy (MOGHE) in the Frontal Lobe

Frontal Disconnection for Treating Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia in Epilepsy (MOGHE) in the Frontal Lobe

Published on: August 16, 2024

Contralateral MRI abnormalities affect seizure and cognitive outcome after hemispherectomy.

K Boshuisen¹, M M J van Schooneveld, F S S Leijten

¹Rudolf Magnus Institute of Neuroscience, Department of Child Neurology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands.

|November 3, 2010

Summary

Contralateral MRI abnormalities predict poor seizure control and cognitive outcomes after functional hemispherectomy in children. EEG abnormalities in the "healthy" hemisphere did not impact results.

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Last Updated: Jun 7, 2026

Frontal Disconnection for Treating Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia in Epilepsy (MOGHE) in the Frontal Lobe

Frontal Disconnection for Treating Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia in Epilepsy (MOGHE) in the Frontal Lobe

Published on: August 16, 2024

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study

Published on: August 15, 2025

Area of Science:

Pediatric Neurology
Neurosurgery
Epileptology

Background:

Functional hemispherectomy is a surgical option for intractable epilepsy.
Predictors of seizure control and cognitive outcome require further investigation.

Purpose of the Study:

To determine if electroencephalogram (EEG) and magnetic resonance imaging (MRI) abnormalities in the non-affected hemisphere influence outcomes after functional hemispherectomy.
To assess the impact of contralateral abnormalities on seizure status and cognitive development.

Main Methods:

Retrospective cohort study of 43 children undergoing functional hemispherectomy (1994-2008).
Preoperative EEG and MRI data were reviewed for contralateral abnormalities.
Seizure freedom (Engel 1A) and cognitive scores (IQ/MDI) were assessed postoperatively.

Main Results:

Seventy-seven percent of children achieved seizure freedom.
Contralateral MRI abnormalities were associated with lower seizure freedom rates (45% vs 88%, p=0.030).
Children with contralateral MRI abnormalities showed worse postoperative cognitive outcomes (90% vs 42% severe delay, p=0.030; no improvement in 100% vs 38%, p=0.034).

Conclusions:

Unequivocal contralateral MRI abnormalities are linked to poor seizure control and cognitive development after hemispherectomy.
Contralateral EEG abnormalities did not negatively affect surgical outcomes.
Contralateral MRI lesions may be a relative contraindication for hemispherectomy.