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Published on: November 4, 2010
Occupational asthma caused by heated triglycidyl isocyanurate
W Anees1, V C Moore, J S Croft
1Occupational Lung Disease Unit, Birmingham Heartlands Hospital, Birmingham B9 5SS, UK.
Occupational Medicine (Oxford, England)
|November 3, 2010
Summary
Heated triglycidyl isocyanurate (TGIC) can cause occupational asthma in bystanders. Even without direct contact, inhaling fumes from heated TGIC may trigger asthma symptoms.
Area of Science:
- Occupational Medicine
- Toxicology
- Respiratory Medicine
Background:
- Triglycidyl isocyanurate (TGIC) is an industrial chemical used in various applications.
- Occupational asthma is a significant workplace health concern, often linked to chemical exposures.
Observation:
- Six workers, exposed as bystanders to heated TGIC fumes, developed symptoms of occupational asthma.
- Diagnostic evaluations, including serial peak expiratory flow measurements and Oasys analysis, confirmed asthma in the affected workers.
Findings:
- Specific inhalation challenge testing with heated TGIC induced late or dual asthmatic reactions in all four tested workers.
- Control subjects and a worker exposed only to unheated TGIC did not exhibit asthmatic reactions, indicating the role of heat in TGIC's asthmogenicity.
Implications:
- Heated TGIC poses a risk for occupational asthma, even for individuals not directly handling the chemical.
- Workplace safety protocols should consider potential bystander exposure to fumes from heated TGIC.
- Further research into the mechanisms of TGIC-induced asthma and effective preventative measures is warranted.
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