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Occupational asthma caused by acrylic compounds from SHIELD surveillance (1989-2014)
G I Walters1, A S Robertson1, V C Moore1
1Occupational Lung Disease Service, Birmingham Chest Clinic, 151 Great Charles Street, Birmingham B3 3HX, UK.
Occupational Medicine (Oxford, England)
|April 22, 2017
Summary
Acrylic compounds cause occupational asthma through respiratory sensitization. This study highlights prevalent exposures and trends in affected workers across various UK industries.
Area of Science:
- Occupational Medicine
- Respiratory Medicine
- Toxicology
Background:
- Acrylic monomers (acrylates, methacrylates, cyanoacrylates) are known respiratory sensitizers causing occupational asthma.
- Inhalation exposures are common in healthcare, dental, beauty, laboratory, assembly, and plastic molding industries.
Purpose of the Study:
- To analyze occupational asthma notifications linked to acrylic compounds.
- To identify prevalent exposure sources and trends in patient presentation within a UK surveillance scheme.
Main Methods:
- Retrospective review of occupational asthma cases reported to the SHIELD surveillance scheme (1989-2014).
- Data collection included demographics, employment, symptoms, and diagnostic tests (serum immunology, peak flow, inhalation challenge).
- Descriptive statistics were used to analyze worker characteristics and sensitization evidence.
Main Results:
- 20 out of 1790 (1%) occupational asthma cases were attributed to acrylic compounds.
- All cases confirmed by Occupational Asthma SYStem (OASYS) serial peak flow analysis; 3 with positive inhalation challenges.
- Exposures occurred in manufacturing, healthcare, beauty, printing, and notably, floor adhesives used by teachers.
Conclusions:
- Acrylic compounds are a significant cause of occupational asthma, as evidenced by this large case series.
- Exposure spans diverse industries, with manufacturing being prominent.
- Acrylic-induced asthma shares similarities with exposures to other sensitizers like isocyanates and epoxy resins.
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