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Related Concept Videos

Drug Concentrations: Measurements01:23

Drug Concentrations: Measurements

Drug concentration is the quantity of a drug present in a biological sample. Measuring drug amounts in biological samples allows the clinician to understand how a drug is absorbed, distributed, metabolized, and excreted. Samples can be obtained through invasive or non-invasive methods. Invasive techniques involve surgical or parenteral interventions to gather blood, cerebrospinal fluid, or tissue biopsy. Conversely, non-invasive approaches provide samples like urine, feces, and saliva.
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Routine Screening Method for Microparticles in Platelet Transfusions
09:49

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Published on: January 31, 2018

High microparticle concentration in cord plasma.

S Schweintzger1, A Schlagenhauf, B Rinner

  • 1Department of Paediatrics, Medical University of Graz, Auenbruggerplatz 30, 8036 Graz, Austria. wolfgang.muntean@meduni-graz.at

Hamostaseologie
|November 3, 2010
PubMed
Summary
This summary is machine-generated.

Newborns have higher microparticle (MP) concentrations and activity in cord plasma compared to adults, impacting their hemostatic system. These findings suggest increased MP activity but not strong platelet activation during birth.

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Area of Science:

  • Hematology
  • Neonatal Physiology
  • Hemostasis and Thrombosis

Background:

  • Microparticles (MPs) are cell-derived vesicles implicated in hemostasis.
  • Understanding MP differences between newborns and adults is crucial for neonatal care.

Purpose of the Study:

  • To investigate differences in microparticle concentration and activity between newborn cord plasma and adult plasma.
  • To assess the impact of microparticles on the neonatal hemostatic system.

Main Methods:

  • Microparticle enumeration and characterization using Flow Cytometry (FACS) and Enzyme-Linked Immunosorbent Assay (ELISA).
  • Assessment of microparticle-derived tissue factor (TF) effect on thrombin generation via calibrated automated thrombography (CAT).

Main Results:

  • Flow cytometry revealed higher microparticle concentrations in newborn cord plasma versus adult plasma.
  • ELISA demonstrated significantly increased procoagulant activity of microparticles in newborn cord plasma.
  • While thrombin generation kinetics differed, the decrease in endogenous thrombin potential (ETP) and peak was comparable between groups.

Conclusions:

  • Newborns exhibit a greater impact of microparticles on their hemostatic system compared to adults.
  • Findings indicate slightly increased microparticle activity in cord plasma, but do not support strong platelet activation during birth.