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Related Concept Videos

Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...

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Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
13:19

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

Prioritizing genes associated with prostate cancer development.

Ivan P Gorlov1, Kanishka Sircar, Hongya Zhao

  • 1Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. ipgorlov@mdanderson.org

BMC Cancer
|November 4, 2010
PubMed
Summary
This summary is machine-generated.

This study identifies key genes driving prostate cancer development and bone metastasis through a comprehensive meta-analysis of gene-expression data. The findings offer a valuable resource for understanding prostate cancer

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Area of Science:

  • Oncology
  • Genetics
  • Bioinformatics

Background:

  • Prostate cancer genetic control remains unclear.
  • Abundant gene-expression data exists for prostate tumorigenesis.
  • This study aimed to identify genes linked to prostate cancer and bone metastasis.

Purpose of the Study:

  • To identify and prioritize candidate genes in prostate cancer development.
  • To leverage meta-analysis of gene-expression data for improved gene discovery.
  • To understand the genetic underpinnings of prostate cancer and bone metastasis.

Main Methods:

  • Utilized Z score-based meta-analysis of gene-expression data.
  • Conducted a 3-level meta-analysis reflecting prostate cancer's natural history.
  • Employed in silico and in-house data for experimental validation of candidate genes.

Main Results:

  • Top candidates included genes with existing evidence of prostate cancer association.
  • Discovered novel candidate genes without prior links to prostate cancer.
  • Identified key functions: cytoskeleton, cell adhesion, extracellular matrix, and motility.
  • Pinpointed 10 hub genes (e.g., CDC2, CCNA2, IGF1) as potential primary drivers.

Conclusions:

  • A 3-level meta-analysis successfully identified candidate genes for prostate cancer development.
  • The generated gene list serves as a resource for prostate cancer research.
  • Further investigation into these genes can elucidate molecular mechanisms of prostate cancer.