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Folate supplementation during methotrexate therapy for rheumatoid arthritis.

S L Morgan1, J E Baggott

  • 1Schools of Health Professions, Medicine, and Dentistry, Birmingham, AL 35294-1270, USA. slmorgan@uab.edu

Clinical and Experimental Rheumatology
|November 4, 2010
PubMed
Summary

Folic acid (FA) and folinic acid (FLN) supplements can reduce methotrexate (MTX) toxicity in rheumatoid arthritis (RA). FA may also improve MTX efficacy by aiding homocysteine metabolism and preventing 7-hydroxy-MTX formation, at a lower cost than FLN.

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