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Related Concept Videos

Protein Glycosylation01:25

Protein Glycosylation

Glycosylation, the most common post-translational modification for proteins, serves diverse functions. Adding sugars to proteins makes the proteins more resistant to proteolytic digestion. Glycosylated proteins can act as markers and receptors to promote cell-cell adhesion. Additionally, they have many essential quality control functions in the cell, such as correct protein folding and facilitating transport of misfolded proteins to the cytosol, which can be degraded.
Glycosylation occurs in...
Globular and Fibrous Proteins02:21

Globular and Fibrous Proteins

Many proteins can be classified into two distinct subtypes - globular or fibrous. These two types differ in their shapes and solubilities.
Globular proteins are also known as spheroproteins and typically are approximately round in shape. They contain a mix of amino acid types and contain differing sequences in their primary structures. Globular proteins have many different functions, such as enzymes, cellular messengers, and molecular transporters. These roles often require the proteins to be...
Gene Families01:57

Gene Families

Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
Chemistry of Carbohydrates03:25

Chemistry of Carbohydrates

Carbohydrates are an essential part of the diet in humans and animals. Grains, fruits, and vegetables are natural sources of carbohydrates that provide energy to the body, particularly through glucose, a simple sugar that is a component of starch and an ingredient in many staple foods. The stoichiometric formula (CH2O)n, where n is the number of carbons in the molecule represents carbohydrates. In other words, the ratio of carbon to hydrogen to oxygen is 1:2:1 in carbohydrate molecules. This...
Chemistry of Carbohydrates03:25

Chemistry of Carbohydrates

Carbohydrates are an essential part of the diet in humans and animals. Grains, fruits, and vegetables are natural sources of carbohydrates that provide energy to the body, particularly through glucose, a simple sugar that is a component of starch and an ingredient in many staple foods. The stoichiometric formula (CH2O)n, where n is the number of carbons in the molecule represents carbohydrates. In other words, the ratio of carbon to hydrogen to oxygen is 1:2:1 in carbohydrate molecules. This...
Chemistry of Carbohydrates03:25

Chemistry of Carbohydrates

Carbohydrates are an essential part of the diet in humans and animals. Grains, fruits, and vegetables are natural sources of carbohydrates that provide energy to the body, particularly through glucose, a simple sugar that is a component of starch and an ingredient in many staple foods. The stoichiometric formula (CH2O)n, where n is the number of carbons in the molecule represents carbohydrates. In other words, the ratio of carbon to hydrogen to oxygen is 1:2:1 in carbohydrate molecules. This...

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Bioinformatics Resources for the Study of Glycan-Mediated Protein Interactions
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Bioinformatics Resources for the Study of Glycan-Mediated Protein Interactions

Published on: January 20, 2022

GlycomeDB--a unified database for carbohydrate structures.

René Ranzinger1, Stephan Herget, Claus-Wilhelm von der Lieth

  • 1German Cancer Research Center, DKFZ, Core Facility, Molecular Structure Analysis, W160, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. rene.ranzinger@glycome-db.org

Nucleic Acids Research
|November 4, 2010
PubMed
Summary
This summary is machine-generated.

GlycomeDB unifies carbohydrate structure and taxonomic data from major databases, creating the most comprehensive resource. This freely accessible database is updated weekly and offers powerful search tools.

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Last Updated: Jun 7, 2026

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Published on: January 20, 2022

Hierarchical and Programmable One-Pot Oligosaccharide Synthesis
09:56

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Published on: September 6, 2019

Biochemical and Structural Characterization of the Carbohydrate Transport Substrate-binding-protein SP0092
08:53

Biochemical and Structural Characterization of the Carbohydrate Transport Substrate-binding-protein SP0092

Published on: October 2, 2017

Area of Science:

  • Glycobiology
  • Bioinformatics
  • Structural Biology

Background:

  • Carbohydrate data is fragmented across multiple public databases.
  • A unified resource is needed for efficient access to carbohydrate structures and taxonomic information.
  • The Protein Data Bank also contains relevant carbohydrate data.

Purpose of the Study:

  • To create a comprehensive and unified resource for carbohydrate structures.
  • To integrate data from major public carbohydrate databases and the Protein Data Bank.
  • To provide flexible search functionalities and regular updates.

Main Methods:

  • Integration of structural and taxonomic data from public carbohydrate databases.
  • Inclusion of carbohydrate data from the Protein Data Bank.
  • Development of a Web interface with advanced search capabilities.
  • Weekly updates to incorporate the newest available structures.

Main Results:

  • GlycomeDB is the most comprehensive and unified resource for carbohydrate structures globally.
  • The database links back to original data sources.
  • The resource is updated weekly with new structures.
  • Flexible and powerful search functionalities are available via a Web interface.

Conclusions:

  • GlycomeDB provides a centralized, up-to-date, and easily searchable platform for carbohydrate research.
  • The database facilitates access to a vast amount of glycomic information.
  • Free download and Web access enhance its utility for the scientific community.