Related Experiment Video
Updated: Jun 7, 2026

11:34
Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers
Published on: December 5, 2017
The Clinical Importance of the Heterogeneity of HER2 neu
1Aventura Comprehensive Cancer Center, Aventura, Fla., USA.
Case Reports in Oncology
|November 4, 2010
Abstract:
We report on a patient with breast cancer in whom there were areas of the tumor that were 3+ positive and negative for HER2 neu by immunohistochemistry, adjacent to each other. Depending on the area tested the results were completely different. The clinical implications are important. We recommend retesting a large portion of the tumor in all cases of initially negative test results.

