Related Experiment Video
Updated: Jun 7, 2026
08:27
Synthesis and Characterization of mRNA-Loaded Poly(Beta Aminoesters) Nanoparticles for Vaccination Purposes
Published on: August 13, 2021
Gene Based Vaccines: Optimising Development and Delivery - A marcus evans Conference.
1Bayhill Therapeutics Inc, 1804 Embarcadero Road, Suite 201, Palo Alto, CA 94303, USA. hgarren@bayhilltx.com
Idrugs : the Investigational Drugs Journal
|November 4, 2010
Summary
This conference report covers advancements in gene-based vaccines, focusing on delivery systems, anti-vector immunity, and applications like influenza and malaria prevention. Key technologies and manufacturing considerations for DNA vaccines were also discussed.
Area of Science:
- Vaccinology
- Molecular Biology
- Immunology
Background:
- The conference addressed emerging therapeutic developments in gene-based vaccine technology.
- Focus areas included optimizing the development and delivery of novel gene-based vaccines.
Framework:
- Discussions covered gene-based vaccine delivery systems and challenges such as anti-vector immunity.
- Prime-boost strategies for influenza vaccines were explored.
- DNA vaccines for malaria prevention were a key topic.
Implementation:
- Selected presentations highlighted the ImmunoBody DNA vaccine technology.
- Considerations for DNA vaccine manufacturing were presented.
- Optimizing gene-based vaccine development and delivery was a central theme.
Implications:
- Advancements discussed have the potential to improve vaccine efficacy and manufacturing processes.
- The findings offer insights into next-generation vaccines for infectious diseases.
- Further research into gene-based vaccine platforms is warranted.
Related Concept Videos
01:23Vaccine Production
Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...
01:30Cancer Vaccines
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
01:29Microorganisms in Medicine and Therapeutics
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
01:21Vaccines
Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the type of...
01:28Preclinical Development: Overview
Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
00:59Gene Therapy
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...