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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Advanced imaging findings in progressive solitary sclerosis: a single lesion or a global disease?
Lisa Eunyoung Lee1, Jillian K Chan1, Emilie Nevill1
1Department of Medicine (Neurology), University of British Columbia, Canada.
Background:
Progressive solitary sclerosis is a unifocal demyelinating disease recently proposed as a possible multiple sclerosis variant.
Objective:
To compare myelin content and brain metabolite ratio qualitatively in the normal-appearing white matter of progressive solitary sclerosis cases compared to multiple sclerosis and healthy control participants.
Methods:
Case report.
Results:
Progressive solitary sclerosis cases showed abnormal myelin in normal-appearing white matter tracts and global normal-appearing white matter as well as lower N-acetyl-aspartate to total creatine ratio compared to multiple sclerosis and healthy control groups.
Conclusion:
Despite a single demyelinating lesion along the corticospinal tract in progressive solitary sclerosis, we showed evidence of more extensive abnormality within the normal-appearing white matter.
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