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Related Concept Videos

Disorders of Leukocytes01:27

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
Structure and Function of Leukocytes01:21

Structure and Function of Leukocytes

An adult in good health typically has between 4,500 and 11,000 leukocytes, or white blood cells, per microliter of blood, which constitutes about 1% of the total blood volume. Unlike red blood cells, white blood cells contain a nucleus and other cellular organelles but do not have hemoglobin. Most white blood cells reside in connective tissues, particularly in lymphatic organs such as the lymph nodes, with only a small fraction present in circulating blood.
White blood cells protect the body...
Disorders of Erythrocytes01:27

Disorders of Erythrocytes

Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
Classification of Leukocytes01:30

Classification of Leukocytes

Leukocytes are classified into two groups based on the presence or absence of cytoplasmic granules. Granular leukocytes, which contain granules, belong to the myeloid lineage and are divided into three subtypes: neutrophils, eosinophils, and basophils. These cells are roughly spherical and characterized by the granules in their cytoplasm.
Neutrophils are the most abundant type of granular leukocytes, comprising 50-70% of all leukocytes. They feature small, evenly distributed granules and a...

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Evaluation of a Point-of-Care Testing Analyzer for Measuring Peripheral Blood Leukocytes
05:58

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Published on: March 22, 2022

Leucocyte counts in anaemia.

K Singh1

  • 1Department of Physiology, Postgraduate Institute of Medical Sciences (PGIMS), University of Health Sciences Rohtak (UHSR), Rohtak 124 001. dr_rb_singh@rediffmail.com

Indian Journal of Physiology and Pharmacology
|November 5, 2010
PubMed
Summary
This summary is machine-generated.

Anemia impacts white blood cell (WBC) counts, including neutrophils and basophils, and alters the neutrophil-to-lymphocyte ratio. These findings suggest a link between anemia and inflammatory markers, impacting patient health outcomes.

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Area of Science:

  • Hematology
  • Clinical Pathology
  • Immunology

Background:

  • Anemia is a common condition often underestimated, affecting quality of life.
  • Elevated white blood cell (WBC) counts are linked to ischemic events and cardiovascular disease.
  • Anemia's association with hypoxia and ischemia suggests a potential impact on WBCs.

Purpose of the Study:

  • To investigate total and differential leukocyte counts (TLC and DLC) in anemic individuals.
  • To assess the neutrophil-to-lymphocyte (N/L) ratio and platelet counts in anemia.
  • To explore the relationship between anemia and WBC parameters.

Main Methods:

  • Comparison of hematological parameters between anemic patients and control groups.
  • Analysis of total and differential leukocyte counts.
  • Evaluation of reticulocyte counts, erythrocyte sedimentation rate, and platelet counts.

Main Results:

  • Anemic subjects showed higher reticulocyte counts and erythrocyte sedimentation rates.
  • Neutrophil and basophil percentages were elevated, while eosinophils and monocytes were decreased in anemic patients.
  • Anemia was associated with an increased N/L ratio and decreased platelet counts.

Conclusions:

  • Leukocyte counts and profiles are significantly altered in patients with anemia.
  • The N/L ratio is increased in anemia, suggesting an inflammatory component.
  • These findings highlight the systemic effects of anemia beyond red blood cell parameters.