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Combinatorial Synthesis of and High-throughput Protein Release from Polymer Film and Nanoparticle Libraries
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Hydrophobic weak acid polymers as controlled release carriers.

Jose M Cornejo-Bravo1, Yareli Partida-Soria, Aracely Serrano-Medina

  • 1Facultad de Ciencias Químicas e Ingeniería, Universidad Autónoma de Baja California, Calzada Universidad 14418, Parque Industrial Internacional, Tijuana, México. jmcornejo@uabc.mx

Pharmaceutical Development and Technology
|November 5, 2010
PubMed
Summary

Poly(carboxyalkyl methacrylates) show pH-sensitive drug release, indicating potential for colon-specific drug delivery systems. Hydrophobicity and pH influence release, with hydrophilic fillers accelerating the rate.

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