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Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
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Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
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Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
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Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
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The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
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Updated: Jun 7, 2026

Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes
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Published on: September 18, 2017

Myocardial dysfunction due to hypocalcemia.

Munesh Tomar1, Sitaraman Radhakrishnan, Savitri Shrivastava

  • 1Department of Pediatrics and Congenital Heart Surgery, Escorts Heart Institute and Research Centre, Okhla Road, New Delhi 110 025, India. muneshtomar@yahoo.co.in

Indian Pediatrics
|November 5, 2010
PubMed
Summary
This summary is machine-generated.

Hypocalcemia, a treatable condition, can cause severe heart dysfunction in infants. Supplementing vitamin D and calcium effectively treated these cases, highlighting its importance in pediatric cardiology.

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Last Updated: Jun 7, 2026

Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes
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Published on: August 1, 2016

Area of Science:

  • Pediatric Cardiology
  • Endocrinology
  • Nutritional Science

Background:

  • Hypocalcemia is an underreported cause of myocardial dysfunction and congestive cardiac failure in infants.
  • Severe left ventricular dysfunction in infants can be linked to electrolyte imbalances.

Purpose of the Study:

  • To describe a cohort of infants with severe left ventricular dysfunction due to hypocalcemia.
  • To identify the primary cause of hypocalcemia in affected infants.
  • To evaluate the efficacy of vitamin D and calcium supplementation in treating these cardiac issues.

Main Methods:

  • Case series describing 15 infants with severe left ventricular dysfunction.
  • Laboratory investigations to assess serum calcium and magnesium levels.
  • Identification of vitamin D deficiency as the etiology for hypocalcemia.

Main Results:

  • All 15 infants presented with severe left ventricular dysfunction.
  • Hypocalcemia was diagnosed in all patients, with hypomagnesemia present in some.
  • Vitamin D deficiency was the predominant cause of hypocalcemia.
  • Significant improvement in cardiac function was observed following vitamin D and calcium supplementation.

Conclusions:

  • Hypocalcemia is a critical, yet reversible, cause of pediatric congestive cardiac failure.
  • Vitamin D deficiency should be considered in infants presenting with unexplained myocardial dysfunction.
  • Prompt diagnosis and treatment with vitamin D and calcium can resolve cardiac issues in affected infants.