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Related Experiment Video

Updated: Jun 7, 2026

Endoscopic Approach for Colloid Cyst Resection
02:30

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Published on: May 23, 2025

Nodular colloid degeneration.

Woo Jin Choi1, Byung Chul Kim, Eun Joo Park

  • 1Department of Dermatology, Hallym University Sacred Heart Hospital, Anyang-si, Gyeonggi-do, South Korea.

The American Journal of Dermatopathology
|November 5, 2010
PubMed
Summary

Nodular colloid degeneration, a rare skin condition, presented as a facial plaque in an elderly man. Histopathology confirmed colloid material in the dermis, highlighting its rarity in medical literature.

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Area of Science:

  • Dermatopathology
  • Histopathology

Background:

  • Nodular colloid degeneration is an exceptionally rare dermatological condition.
  • This report details a unique case encountered in clinical practice.

Observation:

  • A solitary, yellowish, indurated plaque was observed on the left mandibular area of a 76-year-old male patient.
  • The lesion's clinical presentation prompted detailed histopathological investigation.

Findings:

  • Histopathology revealed amorphous colloid material within the upper dermis.
  • Special stains showed negative Congo red staining and no birefringence, but positive elastic staining of the colloid and surrounding fibers.
  • These findings are characteristic of colloid degeneration but emphasize its nodular presentation.

Implications:

  • This case contributes to the limited published data on nodular colloid degeneration.
  • Understanding the histopathological features is crucial for accurate diagnosis of this rare entity.
  • Further research may elucidate the pathogenesis and clinical behavior of this condition.