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A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies
Published on: July 28, 2020
Pulmonary metastasectomy from soft tissue sarcomas.
Rodrigo Afonso da Silva Sardenberg1, Luiz Poli de Figueiredo, Fábio José Haddad
1Department of Thoracic Surgery, Hospital AC Camargo, São Paulo, SP, Brazil. rodafs@uol.com.br
Clinics (Sao Paulo, Brazil)
|November 5, 2010
Summary
Pulmonary metastasectomy for soft tissue sarcoma lung metastases is safe and offers potential long-term survival. Complete resection and fewer metastases are key prognostic factors for better outcomes.
Area of Science:
- Thoracic Surgery
- Surgical Oncology
- Sarcoma Research
Background:
- Pulmonary metastases from soft tissue sarcomas affect 20-50% of patients, often limited to the lungs.
- Surgical resection (pulmonary metastasectomy) is a standard treatment with reported 5-year survival of 30-40%.
- Complete resection is the most consistent predictor of survival.
Purpose of the Study:
- To identify demographic and clinical variables associated with long-term (90-month) overall survival.
- To evaluate outcomes of pulmonary metastasectomy in soft tissue sarcoma patients with lung metastases.
Main Methods:
- Retrospective review of patients undergoing thoracotomy for lung metastasis resection.
- Data collection included primary tumor features, demographics, treatment, and outcomes.
- Analysis of 77 patients with previously treated soft tissue sarcomas.
Main Results:
- 122 thoracotomies and 273 nodules were resected; median follow-up was 36.7 months.
- Postoperative complication rate was 9.1%, with 0% 30-day mortality.
- 90-month overall survival was 34.7%; independent prognostic factors included number of metastases resected, disease-free interval, and number of complete resections.
Conclusions:
- Lung metastasectomy is a safe and potentially curative procedure for soft tissue sarcoma patients.
- A select group of patients can achieve long-term survival following pulmonary resection.
- Complete resection and specific prognostic factors are crucial for long-term outcomes.
