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Related Concept Videos

Reporter Genes02:11

Reporter Genes

Reporter genes are a type of protein-coding gene that are often tagged to a gene of interest. Once inside a target cell, reporter genes usually produce visually identifiable characteristics like fluorescence and luminescence when expressed along with the gene of interest. Thus, reporter genes “report” the presence or absence of genes of interest in an organism, determine the gene expression pattern, or track the physical location of a DNA segment or protein in the cell.
Commonly used reporter...
What is Gene Expression?01:36

What is Gene Expression?

A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is comprised  of nucleotides and proteins are comprised of amino acids, a mediator is required to convert the information encoded in DNA into proteins. This mediator is the messenger RNA (mRNA). mRNA copies the blueprint from DNA by a process called transcription. In eukaryotes, transcription occurs in the nucleus by complementary base-pairing with the DNA template. The mRNA is then processed and...
What is Gene Expression?01:42

What is Gene Expression?

Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
What is Gene Expression?01:42

What is Gene Expression?

Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
The Eukaryotic Promoter Region02:40

The Eukaryotic Promoter Region

The eukaryotic promoter region is a segment of DNA located upstream of a gene. It contains an RNA polymerase binding site, a transcription start site, and several cis-regulatory sequences.  The proximal promoter region is located in the vicinity of the gene and has cis-regulatory sequences and the core promoter. The core promoter is the binding site for RNA polymerase and is usually located between -35 and +35 nucleotides from the transcription start site. The distal promoter regions are...
The Eukaryotic Promoter Region02:40

The Eukaryotic Promoter Region

The eukaryotic promoter region is a segment of DNA located upstream of a gene. It contains an RNA polymerase binding site, a transcription start site, and several cis-regulatory sequences.  The proximal promoter region is located in the vicinity of the gene and has cis-regulatory sequences and the core promoter. The core promoter is the binding site for RNA polymerase and is usually located between -35 and +35 nucleotides from the transcription start site. The distal promoter regions are...

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Updated: Jun 7, 2026

Methods to Discover Alternative Promoter Usage and Transcriptional Regulation of Murine Bcrp1
11:02

Methods to Discover Alternative Promoter Usage and Transcriptional Regulation of Murine Bcrp1

Published on: May 27, 2016

Gene expression. Many mini mind promoters.

Natalie de Souza

    Nature Methods
    |November 5, 2010
    PubMed
    Summary
    This summary is machine-generated.

    New tools enable precise control over gene expression in the brain. This technology allows researchers to restrict specific gene activity, advancing neuroscience research.

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    In vivo Application of the REMOTE-control System for the Manipulation of Endogenous Gene Expression

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    Related Experiment Videos

    Last Updated: Jun 7, 2026

    Methods to Discover Alternative Promoter Usage and Transcriptional Regulation of Murine Bcrp1
    11:02

    Methods to Discover Alternative Promoter Usage and Transcriptional Regulation of Murine Bcrp1

    Published on: May 27, 2016

    AAV Deployment of Enhancer-Based Expression Constructs In Vivo in Mouse Brain
    09:59

    AAV Deployment of Enhancer-Based Expression Constructs In Vivo in Mouse Brain

    Published on: March 31, 2022

    In vivo Application of the REMOTE-control System for the Manipulation of Endogenous Gene Expression
    08:54

    In vivo Application of the REMOTE-control System for the Manipulation of Endogenous Gene Expression

    Published on: March 29, 2019

    Area of Science:

    • Neuroscience
    • Molecular Biology
    • Genetics

    Background:

    • Developing precise tools for gene expression control is crucial for understanding brain function.
    • Existing methods often lack specificity or efficiency in targeting neuronal populations.

    Discussion:

    • This study introduces novel tools designed for restricted gene expression within the brain.
    • These tools offer enhanced spatial and temporal control over targeted genes.
    • The methodology facilitates the study of gene function in specific neural circuits.

    Key Insights:

    • The developed tools demonstrate efficacy in driving restricted gene expression in the brain.
    • Successful application in preclinical models showcases potential for future research.
    • This advancement provides a more refined approach to manipulating gene activity in neurological studies.

    Outlook:

    • Future research can leverage these tools to investigate complex neurological disorders.
    • Further optimization may lead to therapeutic applications for genetic brain conditions.
    • These tools are expected to accelerate discoveries in neurobiology and genetic engineering.