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Published on: September 5, 2018
[Effect of different coating materials on hygroscopicity of compound Luhui granules]
1Department of Pharmaceutical Engineering, Hefei University of technology, Hefei 230009, China. zxxwyfzsy@sina.com
Objective:
To study the effect of different coating materials (hydroxy-propyl methylcellulose, ethylcellulose, polyacrylic resin) on hygroscopicity of granules of traditional Chinese medicine.
Methods:
The methods coated with the single coating material, the complex membrane (coated with two or three kinds of coating materials in turn), the mixed membrane (coated with two or three kinds of coating materials mixed) and the combination of mixed membrane with complex membrane were used, respectively. Taking decreasing percentage of moisture absorption of coated granules as index, the optimum condition of coating technology (the optimum coating method, coating material and its dosage) was optimized by orthogonal test.
Results:
The damp-proof effect of coated with the combination of mixed membrane with complex membrane (decreasing percentage of moisture absorption of coated granules: 35.39%) was better than that of coated with the single coating material (decreasing percentage of moisture absorptions < or = 21.82%), the complex membrane (decreasing percentage of moisture absorption: 30.28%), or the mixed membrane (decreasing percentage of moisture absorption: 31.37%) (P < 0.05).
Conclusion:
The method coated with the combination of mixed membrane (mixed coating materials composed of ethylcellulose and polyacrylic resin) and with complex membrane (coating material composed of HPMC; The granules were coated firstly with the mixed coating materials, followed by HPMC) , obviously reduces the hygroscopicty of compound Luhui granules, and raises the stability of compound Luhui capsules. It is advantageous to the preparation production, storage and application.
