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Published on: May 19, 2023
[Quadratic-orthogonal-rotation-combination design for optimization of ethanol extraction craft from Radix Paeoniae
Xiao-Xia Peng1, Zhen-Wei Zhang
1Gansu college of Traditional Chinese Medicine, Lanzhou 730000, China. pengxiaoxia@gszy.edu.cn
Objective:
To optimize the ethanol extraction process of Radix Paeoniae Rubra (RPR) using quadratic-orthogonal-rotation-combination design.
Methods:
The influential factors were ethanol volume, ethanol concentration and extracting time. The evaluating indicator was the extraction rate of peoniflorin. The quadratic-orthogonal-rotation-combination design was used to optimize the process and the prediction was carried out.
Results:
The optimum conditions of extraction were 73% ethanol, 100 min for extraction, volume of ethanol was 8. 3 times.
Conclusion:
It shows that the optimum model is simple and highly predictive.
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