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Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...

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Related Experiment Video

Updated: Jun 7, 2026

Antigenic Liposomes for Generation of Disease-specific Antibodies

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

Peanut allergy and anaphylaxis.

Fred D Finkelman¹

¹Department of Medicine, Cincinnati Veterans Affairs Medical Center, Cincinnati, OH 45220, United States. ffinkelman@pol.net

Current Opinion in Immunology

|November 6, 2010

Summary

This summary is machine-generated.

Recent advances in understanding peanut allergy reveal that early oral exposure may prevent allergy, while non-oral exposure might increase it. Promising treatments include oral immunotherapy and novel therapies for peanut-induced anaphylaxis.

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Non-destructive SPE-UPLC-based Quantification of Aflatoxins and Stilbenoid Phytoalexins in Single Peanut (Arachis spp.) Seeds

Non-destructive SPE-UPLC-based Quantification of Aflatoxins and Stilbenoid Phytoalexins in Single Peanut (Arachis spp.) Seeds

Published on: April 19, 2024

Area of Science:

Immunology
Allergology
Clinical Medicine

Background:

Peanuts are a significant cause of food allergy and fatal anaphylaxis in the U.S.
Recent research has advanced the understanding of peanut allergens and allergy.
Key areas include prevalence, etiology, diagnosis, and therapy.

Purpose of the Study:

To review recent advances in peanut allergy research.
To highlight new findings on peanut allergens and allergy management.
To summarize progress in understanding peanut allergy's global variations and treatment.

Main Methods:

Literature review of recent studies on peanut allergy.
Analysis of research on peanut allergen importance, prevalence, and etiology.
Evaluation of emerging diagnostic and therapeutic strategies.

Main Results:

Geographical variations exist in the primary peanut allergens.
Early oral peanut exposure may reduce allergy incidence; non-oral exposure may increase it.
Complement activation by peanut components may drive anaphylaxis; oral immunotherapy, anti-IgE, and herbal formulations show therapeutic promise.

Conclusions:

Understanding peanut allergy is rapidly evolving.
Early exposure strategies and novel therapies offer new hope for management.
Further research is needed to confirm the efficacy and safety of new treatments.