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Updated: Jun 7, 2026

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells
09:03

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells

Published on: November 23, 2014

[Tumor angiogenesis: recent progress and remaining challenges]

J-J Feige1

  • 1Unité Inserm 878, iRTSV-LAPV, CEA-Grenoble, Grenoble Cedex 09, France. jean-jacques.feige@cea.fr

Bulletin Du Cancer
|November 6, 2010
PubMed

Insights

Anti-angiogenic therapies target tumor blood vessels to treat cancers like colon and lung cancer. However, understanding tumor resistance mechanisms is crucial for improving treatment efficacy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Context:

  • Anti-angiogenic therapies are a novel treatment for solid tumors, improving survival in various cancers.
  • Tumor resistance significantly limits the efficacy of these therapies.

Purpose:

  • To review the molecular and cellular mechanisms of tumor angiogenesis.
  • To describe the factors controlling angiogenesis activation and maturation.
  • To discuss the efficacy, limits, and resistance mechanisms of current anti-angiogenic therapies.

Summary:

  • This review details tumor angiogenesis, focusing on hypoxia, vascular endothelial growth factor (VEGF), and endothelial tip cells.
  • It explains the mechanisms of angiogenesis activation and maturation.
  • The review also covers the effectiveness and limitations of existing anti-angiogenic drugs and explores emerging resistance mechanisms.

Impact:

  • Provides a comprehensive overview of tumor angiogenesis and anti-angiogenic therapy resistance.
  • Highlights the need for further research into overcoming therapeutic limitations.
  • Informs the development of more effective cancer treatment strategies.

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