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Related Experiment Video

Updated: Jun 7, 2026

Subretinal Transplantation of Human Embryonic Stem Cell Derived-retinal Pigment Epithelial Cells into a Large-eyed Model of Geographic Atrophy
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Subretinal Transplantation of Human Embryonic Stem Cell Derived-retinal Pigment Epithelial Cells into a Large-eyed Model of Geographic Atrophy

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Retinal point-spread function after corneal transplantation for Fuchs' dystrophy.

Loren S Seery1, Jay W McLaren, Katrina M Kittleson

  • 1Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA.

Investigative Ophthalmology & Visual Science
|November 6, 2010
PubMed
Summary

Corneal transplantation for Fuchs' dystrophy degrades retinal optics, impacting visual acuity. Older recipient age further worsens outcomes after Descemet stripping with endothelial keratoplasty (DSEK) due to host cornea retention.

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Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases
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Last Updated: Jun 7, 2026

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Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases

Published on: June 14, 2021

Area of Science:

  • Ophthalmology
  • Corneal Surgery
  • Retinal Optics

Background:

  • Fuchs' dystrophy is a progressive corneal disease affecting endothelial cells.
  • Corneal transplantation, including Descemet stripping with endothelial keratoplasty (DSEK) and penetrating keratoplasty (PK), is a common treatment.
  • Understanding the impact of these procedures on retinal optical quality is crucial for visual outcomes.

Purpose of the Study:

  • To evaluate the effect of corneal transplantation for Fuchs' dystrophy on retinal point-spread function domains.
  • To assess the influence of recipient age on these optical outcomes.

Main Methods:

  • Measurement of retinal stray light (large-angle domain) and point-spread function 50% width (small-angle domain).
  • Comparison between pseudophakic eyes post-DSEK (30), post-PK (10), and normal pseudophakic eyes (30).
  • Correlation analysis with high-contrast visual acuity (HCVA) and recipient age using generalized estimating equation models.

Main Results:

  • Eyes post-DSEK or PK showed increased 50% width compared to normal eyes (P < 0.001).
  • HCVA correlated with 50% width and stray light after DSEK, and with 50% width after PK.
  • Stray light correlated with recipient age after DSEK (r = 0.67, P < 0.001) but not after PK or in normal eyes.

Conclusions:

  • Degradation of the small-angle domain post-DSEK indicates aberrations contributing to reduced visual acuity.
  • Poorer optical quality in older DSEK recipients is linked to the retained host cornea.