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Updated: Jun 7, 2026
09:33
Quantitative 3D In Silico Modeling (q3DISM) of Cerebral Amyloid-beta Phagocytosis in Rodent Models of Alzheimer's Disease
Published on: December 26, 2016
Inflammation and Alzheimer's disease.
Young-Jung Lee1, Sang Bae Han, Sang-Yoon Nam
1College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, Korea.
Archives of Pharmacal Research
|November 6, 2010
Summary
Alzheimer's disease (AD) involves brain inflammation and neuron loss. Anti-inflammatory drug use suggests a link between neuroinflammation and AD, prompting a review of AD pathogenesis and treatments.
Area of Science:
- Neuroscience
- Pathology
- Pharmacology
Background:
- Alzheimer's disease (AD) is the most common dementia, marked by beta-amyloid plaques and neuron loss.
- Neuroinflammation, indicated by inflammatory markers and activated microglia, is implicated in AD pathogenesis.
- Epidemiological studies suggest non-steroidal anti-inflammatory drugs may delay AD onset, highlighting the neuroinflammation-AD link.
Purpose of the Study:
- To assess the association between neuroinflammation and Alzheimer's disease.
- To review current and potential treatment strategies for AD.
Main Methods:
- Review of experimental and clinical studies on Alzheimer's disease.
- Analysis of neuroinflammation markers in AD brains.
- Evaluation of epidemiological data on anti-inflammatory drug use and AD.
Main Results:
- Evidence indicates a significant role of neuroinflammation in AD pathogenesis.
- Accumulation of activated microglia and elevated inflammatory cytokines are observed in AD brains.
- Long-term use of NSAIDs correlates with suppressed AD progression.
Conclusions:
- Neuroinflammation is a critical factor in Alzheimer's disease development and progression.
- Targeting neuroinflammation presents a promising therapeutic avenue for AD treatment and prevention.
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