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04:39
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
Cases of interferon-alpha and interferon-beta-induced thyroiditis.
1Clinic of Endocrinology and Metabolic Diseases, Medical University, Plovdiv, Bulgaria.
Folia Medica
|November 9, 2010
Summary
Interferon therapy can cause thyroid disorders in 1-35% of patients, leading to treatment changes. This review covers interferon-induced thyroid dysfunction, risk factors, and management strategies.
Area of Science:
- Endocrinology
- Immunology
- Oncology
Background:
- Interferons are key treatments for various cancers and viral infections.
- Thyroid dysfunction is a known complication of interferon therapy, affecting 1-35% of patients.
- These thyroid issues can necessitate interferon dose reduction or discontinuation.
Purpose of the Study:
- To review the frequency, characteristics, risk factors, and mechanisms of interferon-induced thyroid disorders.
- To summarize the detection and treatment of these complications.
- To highlight the need for further research into thyroid function in specific patient groups receiving interferon.
Main Methods:
- Literature review of studies on interferon-induced thyroid disorders.
- Analysis of genetic and non-genetic risk factors.
- Summary of clinical data on incidence, characteristics, and management.
Main Results:
- Interferon-induced thyroid disorders include autoimmune and non-autoimmune thyroiditis.
- Risk factors encompass genetic elements (sex, age, genes) and non-genetic factors (underlying disease, interferon regimen, iodine, baseline autoantibodies).
- Data is more extensive for hepatitis C and multiple sclerosis patients than for hematological malignancies.
Conclusions:
- Early detection and management of thyroid dysfunction are crucial to prevent treatment compromise.
- Further research is needed to elucidate the specific influences of interferon drugs and underlying diseases on thyroid function.
- Understanding these factors can optimize patient care and treatment outcomes.
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