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Updated: Jun 7, 2026

Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology
Published on: March 12, 2015
Cu-catalyzed efficient synthetic methodology for ebselen and related Se-N heterocycles
Shah Jaimin Balkrishna1, Bhagat Singh Bhakuni, Deepak Chopra
1Department of Chemistry, Indian Institute of Science Education and Research Bhopal (IISER), Bhopal, MP 462 023, India.
Abstract:
An efficient copper-catalyzed method for the synthesis of biologically important ebselen and related analogues containing a Se-N bond has been developed. This is the first report of a catalytic process of selenation and Se-N bond formation reaction. Copper-catalyzed reaction tolerates functional groups such as amides, hydroxyls, ethers, nitro, fluorides, and chlorides. The best results are obtained by using a combination of potassium carbonate as a base, iodo- or bromo-arylamide substrates, selenium powder, and copper iodide catalyst.
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