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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

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Related Experiment Video

Updated: Jun 7, 2026

Injection of Syngeneic Murine Melanoma Cells to Determine Their Metastatic Potential in the Lungs
07:31

Injection of Syngeneic Murine Melanoma Cells to Determine Their Metastatic Potential in the Lungs

Published on: May 24, 2016

Cutaneous metastases from internal malignancies.

Dorothée Nashan1, Frank Meiss, Markus Braun-Falco

  • 1Department of Dermatology, University Medical Center Freiburg, Freiburg, Germany. dorothee.nashan@uniklinik-freiburg.de

Dermatologic Therapy
|November 9, 2010
PubMed
Summary
This summary is machine-generated.

Cutaneous metastases, or skin spread from internal cancers, may be underdiagnosed. This review covers their clinical presentation, prognosis, and emerging treatments for better detection and management.

Related Experiment Videos

Last Updated: Jun 7, 2026

Injection of Syngeneic Murine Melanoma Cells to Determine Their Metastatic Potential in the Lungs
07:31

Injection of Syngeneic Murine Melanoma Cells to Determine Their Metastatic Potential in the Lungs

Published on: May 24, 2016

Area of Science:

  • Oncology
  • Dermatology
  • Pathology

Background:

  • Cutaneous metastases from internal malignancies are reported with varying incidence rates (up to 10.4%).
  • Clinical presentation and behavior of skin metastases are often similar regardless of the primary cancer's origin.
  • There is a suspicion of underdiagnosis due to focus on more advanced disease aspects.

Purpose of the Study:

  • To critically review the current knowledge on the clinical presentation, prognosis, and therapeutic strategies for cutaneous metastases.
  • To enhance awareness and improve the diagnosis of skin metastases from internal cancers.
  • To explore advancements in treatment beyond local excision.

Main Methods:

  • Review of clinical presentations categorized by organ systems.
  • Analysis of specific features and differential diagnoses for cutaneous metastases.
  • Critical evaluation of existing and emerging therapeutic concepts, including chemotherapy and immunotherapy.

Main Results:

  • Cutaneous metastases exhibit consistent morphology and behavior irrespective of the primary tumor site.
  • General survival for patients with cutaneous metastases is often less than 12 months.
  • Excision remains the primary local treatment, with ongoing research into systemic therapies.

Conclusions:

  • Increased awareness is crucial as current survival paradigms may be insufficient.
  • Further research into tumor-specific chemotherapeutic and immunological approaches is warranted.
  • A comprehensive understanding of clinic, prognosis, and therapy is essential for managing cutaneous metastases.