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Related Concept Videos

Pedigree Analysis01:35

Pedigree Analysis

Overview
Sex-linked Disorders01:43

Sex-linked Disorders

Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Sex Linked Disorders01:43

Sex Linked Disorders

Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
Inheritance01:25

Inheritance

Gregor Mendel's pioneering work on the principles of inheritance fundamentally transformed our understanding of how traits are transmitted from generation to generation. His experiments with pea plants laid the groundwork for the discovery of genes, discrete units within organisms that control heredity.
Each gene exists in pairs, and the combination of these genes from both parents forms an individual's genotype. This genotype is a blueprint of potential traits. Examples of genotype traits...
Genetic Lingo01:11

Genetic Lingo

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In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
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Published on: August 20, 2019

Inherited syndromes.

Melissa A Reyes1, Daniel B Eisen

  • 1University of California Davis Medical Center, Sacramento, California, USA.

Dermatologic Therapy
|November 9, 2010
PubMed
Summary

Recognizing inherited skin conditions (genodermatoses) can lead to early detection of internal cancers. This improves patient outcomes and life expectancy through established screening and treatment protocols.

Area of Science:

  • Medical Genetics
  • Dermatology
  • Oncology

Background:

  • Inherited skin conditions, known as genodermatoses, are frequently linked to internal malignancies.
  • Early identification of these genodermatoses is crucial for timely cancer detection.

Purpose of the Study:

  • To review dermatologic, clinical, and laboratory findings of genodermatoses associated with internal malignancies.
  • To explore appropriate screening and treatment recommendations for these patients.

Main Methods:

  • Literature review of genodermatoses with associated internal malignancies.
  • Synthesis of diagnostic findings and management guidelines.

Main Results:

  • Genodermatoses present with specific cutaneous, clinical, and laboratory findings that signal potential internal malignancies.

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  • Established screening and treatment protocols exist for several of these syndromes.

    • Conclusions:

    • Clinicians can identify genodermatoses through cutaneous manifestations, enabling early diagnosis of internal malignancies.
    • Utilizing established protocols for genodermatoses can improve patient prognosis and life expectancy.