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Characterizing DNA Repair Processes at Transient and Long-lasting Double-strand DNA Breaks by Immunofluorescence Microscopy
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DNA double-strand break signaling and human disorders

Toshiyuki Bohgaki1, Miyuki Bohgaki1, Razqallah Hakem1

  • 1Ontario Cancer Institute, University Health Network and Department of Medical Biophysics, University of Toronto, 610 University Avenue, Toronto, M5G 2M9 Ontario, Canada.

Genome Integrity
|November 9, 2010
PubMed
Summary

DNA double-strand breaks require precise signaling and repair pathways like homologous recombination and non-homologous end-joining to maintain genomic integrity. Impaired signaling of these critical DNA lesions is linked to severe human diseases.

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