Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Cirrhosis II: Pathophysiology01:24

Cirrhosis II: Pathophysiology

Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to structural...
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of Celiac Disease After Immunotherapy: A Case Series.

Gastro hep advances·2026
Same author

A machine learning model of lamina propria fibrosis in eosinophilic esophagitis for prediction of fibrostenotic disease.

Journal of pathology informatics·2026
Same author

Morphological characterization of a novel model of steatohepatitis in the <i>FAH</i><sup><i>-/-</i></sup> pig.

Veterinary pathology·2026
Same author

Mucinous cystic neoplasms of the pancreas demonstrate <i>in situ</i> production of estrogen.

Frontiers in cell and developmental biology·2025
Same author

Metastatic Epstein-Barr Virus-Associated Lymphoepithelioma-Like Carcinoma of Small Bowel Origin.

Case reports in oncology·2025
Same author

Histopathologic evaluation of gastrointestinal graft-versus-host disease: Opportunities for improvement based on a survey of practicing pathologists.

Annals of diagnostic pathology·2025

Related Experiment Video

Updated: Jun 7, 2026

Long Term Intravital Multiphoton Microscopy Imaging of Immune Cells in Healthy and Diseased Liver Using CXCR6.Gfp Reporter Mice
11:44

Long Term Intravital Multiphoton Microscopy Imaging of Immune Cells in Healthy and Diseased Liver Using CXCR6.Gfp Reporter Mice

Published on: March 24, 2015

Hepatic granulomas: pathogenesis and differential diagnosis.

Stephen M Lagana1, Roger K Moreira, Jay H Lefkowitch

  • 1Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032, USA. sml9012@nyp.org

Clinics in Liver Disease
|November 9, 2010
PubMed
Summary

Granulomatous liver disease, found in 4% of liver biopsies, involves T-cell and macrophage interactions. Causes range from infections and immune disorders to drug toxicity and cancer.

More Related Videos

Selective Harvesting of Marginating-hepatic Leukocytes
06:53

Selective Harvesting of Marginating-hepatic Leukocytes

Published on: July 21, 2016

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
10:04

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Published on: September 5, 2017

Related Experiment Videos

Last Updated: Jun 7, 2026

Long Term Intravital Multiphoton Microscopy Imaging of Immune Cells in Healthy and Diseased Liver Using CXCR6.Gfp Reporter Mice
11:44

Long Term Intravital Multiphoton Microscopy Imaging of Immune Cells in Healthy and Diseased Liver Using CXCR6.Gfp Reporter Mice

Published on: March 24, 2015

Selective Harvesting of Marginating-hepatic Leukocytes
06:53

Selective Harvesting of Marginating-hepatic Leukocytes

Published on: July 21, 2016

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
10:04

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Published on: September 5, 2017

Area of Science:

  • Hepatology
  • Immunology
  • Pathology

Background:

  • Granulomatous liver disease affects approximately 4% of liver biopsies.
  • Hepatic granulomas form from T lymphocyte and macrophage interactions, influenced by T-helper 1 or T-helper 2 pathways.
  • Clinical signs include elevated alkaline phosphatase and g-glutamyltransferase, bile duct damage, or progressive liver disease.

Purpose of the Study:

  • To discuss the causes and epidemiologic trends of granulomas in the liver.
  • To provide an overview of the pathogenesis and clinical manifestations of granulomatous liver disease.

Main Methods:

  • Review of existing literature on granulomatous liver disease.
  • Analysis of diagnostic criteria and causative factors.
  • Discussion of clinical presentations and outcomes.

Main Results:

  • Identified systemic immunologic disorders, infectious diseases, drug hepatotoxicity, and neoplastic disease as major causes.
  • Highlighted the role of T-helper 1/T-helper 2 pathways in granuloma formation.
  • Noted clinical manifestations such as enzyme elevation and structural damage.

Conclusions:

  • Granulomatous liver disease has diverse etiologies and clinical presentations.
  • Understanding the underlying causes and immune pathways is crucial for diagnosis and management.
  • Further research into epidemiologic trends can inform public health strategies.