Related Experiment Video
Updated: Jun 6, 2026
11:46
Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice
Published on: April 27, 2014
[Specific treatments for painful bladder syndrome]
J Rigaud1, D Delavierre, L Sibert
1Clinique urologique, centre fédératif de pelvipérinéologie, hôpital Hôtel Dieu, CHU de Nantes, 1, place Alexis-Ricordeau, 44000 Nantes, France. jrigaud@chu-nantes.fr
Summary
Treatments for painful bladder syndrome, including intravesical and oral options, show limited efficacy. Further research is needed for effective painful bladder syndrome management.
Area of Science:
- Urology
- Pain Management
Context:
- Painful bladder syndrome (PBS) is a chronic condition characterized by pelvic pain, urinary urgency, and frequency.
- Current understanding of PBS pathophysiology is incomplete, leading to diverse and often ineffective treatment strategies.
Purpose:
- To review the current treatment landscape for painful bladder syndrome.
- To evaluate the efficacy of various proposed therapeutic modalities for PBS.
Summary:
- A literature review identified numerous intravesical and oral treatments for PBS, including glucosaminoglycan (pentosan polysulfate), DMSO, heparin, BCG, anticholinergics, antihistamines, and antidepressants.
- Salvage treatments such as neuromodulation, botulinum toxin, and surgery have also been explored.
- The efficacy of most treatments is limited, with studies often lacking robust design and sufficient patient numbers, leading to discordant results.
Impact:
- The complex nature of PBS and the variable efficacy of existing treatments highlight the need for more rigorous research.
- Improved understanding and development of evidence-based treatments are crucial for better patient outcomes in painful bladder syndrome.
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