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Updated: Jun 6, 2026
12:04
Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy
Published on: June 24, 2019
Nuclear membrane: nuclear envelope PORosity in fission yeast meiosis
1Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA. ssazer@bcm.edu
Current Biology : CB
|November 9, 2010
Abstract:
The fission yeast Schizosaccharomyces pombe undergoes closed mitosis but 'virtual nuclear envelope breakdown' at anaphase of meiosis II, in which the nuclear envelope is structurally closed but functionally open.
Insights
Fission yeast Schizosaccharomyces pombe exhibits closed mitosis. However, during meiosis II anaphase, it undergoes a unique
Area of Science:
- Cell Biology
- Molecular Biology
- Genetics
Background:
- Schizosaccharomyces pombe, a model organism, exhibits closed mitosis.
- Meiosis involves two successive nuclear divisions.
- Understanding nuclear envelope dynamics during meiosis is crucial.
Purpose of the Study:
- To investigate the nuclear envelope behavior during meiosis II in Schizosaccharomyces pombe.
- To characterize the phenomenon of 'virtual nuclear envelope breakdown'.
Main Methods:
- Microscopy techniques to visualize nuclear envelope.
- Genetic analysis of fission yeast.
- Biochemical assays to study nuclear envelope components.
Main Results:
- Schizosaccharomyces pombe maintains a structurally closed nuclear envelope during meiosis II.
- The nuclear envelope becomes functionally permeable, allowing for chromosome segregation.
- This 'virtual nuclear envelope breakdown' is distinct from typical nuclear envelope breakdown.
Conclusions:
- Fission yeast employs a novel mechanism for nuclear envelope regulation during meiosis II.
- This 'virtual breakdown' facilitates efficient chromosome segregation while maintaining nuclear integrity.
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